The FTSE 100 is expected start the last session of a turbulent week in negative territory, with financial spread betting firms indicating a loss of around 32 points at the start of trading.
Recent volatility in global equities, commodity prices, along with currency movements and mixed economic data, continues to rattle investors, causing US markets to lose further ground overnight.
Asian markets were also lower this morning.
Yesterday's announcement from the Bank of England, hinting that a rate rise could come earlier and by a greater extent than previously expected, added an additional element of uncertainty into the mix.
Nevertheless, policymakers at the BoE voted unanimously to keep interest rates on hold at 0.5% at their latest meeting.
Manufacturing and industrial production data and the latest goods trade balance, due later this morning, may provide an additional trigger for traders in the absence of any major Corporate news.
On Wall Street overnight, the Dow fell 1,032.89 points, or 4.15%, to end the session at 23,860.46.
The S&P 500 lost 100.66 points, or 3.75%, to close at 2,581 and NASDAQ finished 274.83 points lower at 6,777.16.
In Asia this morning, the Nikkei 225 was down 576.11 points, or 2.63%, at 21,314.75 heading into the close.
Meanwhile, the Hang Seng was 1,144.86 points, or 3.76%, lower at 29,306.41.
At around 6:15am, WTI crude was 0.62% lower at $60.53 per barrel and Brent was down 0.65% at $64.39 per barrel.
Gold was 0.07% firmer at $1,319.9 per ounce, silver was up 0.02% but copper was 0.54% lower.
Trading Statements: Victrex.
AGM's / EGM's: GCP Infrastructure Investments, Port Erin Biopharma Investments, Shaftesbury and Victrex.
Economic News: Manufacturing and industrial production data, the latest goods trade balance and construction output figures.